Insomnia tied to depression cardiovascular disease

first_imgDimaBerlin/ Insomnia tied to depression, cardiovascular disease Click to view the privacy policy. Required fields are indicated by an asterisk (*) Insomnia, often blamed on stress or bad sleep habits, may instead be closely linked to depression, heart disease, and other physiological disorders, a pair of deep dives into the human genome now reveals.“Both studies are very well done,” says psychologist Philip Gehrman of the University of Pennsylvania’s Perelman School of Medicine, who researches sleep behavior. Still, he stresses that much more work remains before the genetic connections to insomnia can be translated to new therapies for patients.Insomnia costs the U.S. workforce more than $63 billion each year in lost productivity, according to some estimates. It’s also incredibly common: As much as a third of the worldwide population suffers from insomnia-related symptoms at any given time. Yet the disorder remains poorly understood. Sign up for our daily newsletter Get more great content like this delivered right to you! Country Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Email By Michael PriceFeb. 25, 2019 , 12:10 PM In one new paper reported today in Nature Genetics, researchers led by geneticist Danielle Posthuma of Vrije Universiteit in Amsterdam conducted a genome-wide association study (GWAS), which looks for links between shared sequences of DNA and particular behaviors or clinical symptoms. The group analyzed the genomes of more than 1 million people, which the authors say is the largest GWAS to date. The data came from UK Biobank, a long-running, enormous U.K. genetics study, and the private genetics firm 23andMe. The prevalence of insomnia in the people covered by both databases was about 30%, which is in line with estimates for the general population.The scientists ultimately turned up 956 genes that predicted some level of insomnia risk. Many have been previously associated with depression, neuroticism, diabetes, and cardiovascular disease, yet they are only weakly linked to other sleep characteristics, such as quality of sleep and being a morning or night person. The team also found a link between insomnia and MEIS1, a gene previously tied to restless leg syndrome.In another study appearing today in Nature Genetics, a different team also ran a GWAS on insomnia. The researchers, led by geneticist Richa Saxena of Massachusetts General Hospital in Boston, looked at 453,379 genomes. They found 57 chromosomal locations containing approximately 236 genes that are associated with insomnia symptoms. MEIS1 was one of them as well, and again there appeared to be a link between insomnia and genes involved with depression, coronary artery disease, and poorer self-reported quality of life. What’s more, the team’s analysis suggests insomnia can cause symptoms of depression and heart disease in some people.“Insomnia is an important sleep disorder to be taken seriously, both for its impact on quality of life … and on future depression and heart disease,” Saxena says.Identifying these genetic targets could allow researchers to more effectively tailor medicines and therapies, Posthuma says. For example, drugmakers could hunt for molecules that tamp down the activity of some of these genes. Alternatively, existing treatments for depression, such as antidepressants or cognitive behavioral therapy, might also help ease insomnia symptoms, Posthuma says.Pinpointing the right targets out of the hundreds of gene candidates suggested by these studies will be the next difficult step, Gehrman says. Scientists, he notes, need “to figure out which ones are ‘real’ or just random associations.”last_img

Leave a Reply

Your email address will not be published. Required fields are marked *