The MGH team’s innovative spin on the technique involves the use of an injectable ice “slurry,” a sterile solution of normal saline and glycerol (a common food ingredient) containing approximately 20 percent to 40 percent small ice particles, similar in texture to slush. The solution can be injected directly into fat deposits, causing the fat cells (adipocytes) to crystallize and die and fat deposits to shrink. The killed adipocytes are gradually eliminated by the body over a period of weeks. “One of the cool things about this is how the injected slurry causes selective effects on fat,” said Rox Anderson, a co-author and leader of the Wellman Center. “Even if the slurry is injected into other tissue such as muscle, there is no significant injury.”As the investigators report, injection of the ice solution into pigs resulted in a 55 percent reduction in fat thickness compared to that of pigs injected with the same but melted ice solution. There was no damage to skin or muscle at the injection site, and no systemic side effects or abnormalities seen.Unlike topical cooling, slurry injection can target and remove fat tissue at essentially any depth and any site that can be accessed by a needle or catheter. Injection of physiological ice slurry could be a transformative method for nonsurgical body contouring.Other authors of the Plastic and Reconstructive Surgery paper include Sara Moradi Tuchayi, Emilia Javorsky, William A. Farinelli, Ying Wang, Martin Purschke, Josh Tam. The research was done at the Wellman Center at MGH and the Department of Dermatology at Harvard Medical School, Boston, Peiyun Ni from Harvard Medical School, and Christine G. Lian from the Brigham & Women’s Hospital Department of Pathology.Disclosure: Anderson, Farinelli, Garibyan, and Javorsky are inventors in patents related to this work, which are owned by the Massachusetts General Hospital. Javorsky currently works for Arctic Fox Biomedical, which has licensed the patent for this invention to develop into a commercial product. The inventors have received part of a license fee according to institutional policy. The authors declare no other competing interests. This research was supported by sundry funds. The Daily Gazette Sign up for daily emails to get the latest Harvard news. How cool is this: the Massachusetts General Hospital (MGH) laboratory that invented cryolipolisis or “Coolsculpting,” a popular nonsurgical method for reducing fat under the skin, is developing a new form of the technology that can selectively reduce fat almost anywhere in the body using a safe, injectable ice solution or “slurry.”The technology, not yet approved for use in humans, is designed for removal of fat in the abdomen or other parts of the body — virtually anywhere that can be reached with a hypodermic needle. Fat is a normal part of our bodies, but in excess or with some diseases can be life-threatening.The new technique is described in a paper published online ahead of print in the journal Plastic and Reconstructive Surgery. As one of the reviewers of the paper said, “this treatment has the potential to become one of the most performed cosmetic procedures in plastic surgery practice.”“The appeal of this technique is that it’s easy and convenient to do,” says lead author Lilit Garibyan, investigator in the Wellman Center for Photomedicine at MGH and the Department of Dermatology at Harvard Medical School. “With Coolsculpting, which is a topical cooling technique, the patient has to sit there for almost an hour for enough heat to diffuse from the fat underneath the skin. With this new technique the doctor can do a simple injection that takes just less than a minute, the patient can go home, and then the fat gradually disappears.”Cryolipolysis is currently the leading noninvasive fat removal technology because of its minor side effects and noninvasive nature. The Coolsculpting method is limited, however, by the amount of fat that can be removed per treatment, and is not practical for reaching more deeply seated fat surrounding organs or other body structures. “With this new technique the doctor can do a simple injection that takes just less than a minute, the patient can go home, and then the fat gradually disappears.” — Lilit Garibyan
How the institute converted a clinical processing lab into a large-scale COVID-19 testing facility in a matter of days Harvard to help track the virus As the COVID-19 pandemic has continued to worsen, other organizations facing their own problems have turned to the Wyss Institute for help. Beth Israel Deaconess Medical Center, facing a distressing shortage of the nasopharyngeal swabs used to diagnose COVID-19 (which are manufactured in northern Italy), reached out to Ingber, the Wyss Institute’s founding director, asking for help. Ingber relayed the message to his colleagues, and a group of researchers immediately began working on a solution in the form of injection-molded swabs that could be mass-manufactured quickly. The team is currently working with clinical and industrial partners to test their design’s effectiveness and scalability, and are working with their clinical collaborators to begin testing them in patients within the week.“I am extremely proud of how quickly the Wyss Institute has come together to fight COVID-19 in such a short period of time,” Ingber said. “It all pulled together over one weekend. All of the teams are deploying their unique skills and approaches to fight this virus in a highly interdisciplinary and openly collaborative way, and I am confident that our contributions will help bring this pandemic to an end.” Facing a pandemic, Broad does a quick pivot Students from Chan School are helping to boost the volunteer public health workforce Related Expects to have 1,000 face shields by end of week On March 13, as cases of COVID-19 ballooned across the globe, hundreds of researchers at the Wyss Institute at Harvard University were directed to work from home within five days to minimize the risk of infection. The only people who would be allowed in the buildings after that point would be those performing critical functions like taking care of animals and maintaining equipment, or those working on fighting the novel coronavirus pandemic.By the following Wednesday, more than 40 people from six teams of scientists at the Institute had submitted petitions to shift their focus entirely to COVID-19, voluntarily putting their own research on hold in exchange for spending long, lonely days and nights in mostly-deserted labs, racing to fight a foe that they couldn’t see but knew was very, very real.“It was self-assembly at its best — the spontaneous coalescence of teams of people who said, ‘I want to work on solving this problem,’ rather than ‘That’s not my job,” said Ayis Antoniou, the Wyss Institute’s Director of Administration. “The way people reacted to this crisis is exactly how they react to new situations every day at the Wyss Institute — the world changed, so we changed with it.”Keeping an institute open, remotelyMembers of the Wyss operations, administration, information technology, human Resources, and communications teams have come together to support our scientists in the lab remotely. This group photo was taken at the annual Wyss Institute retreat in November.While the decision to allow and support COVID-19 research may have been a no-brainer, actually figuring out how to do that in the midst of shifting to remote work proved to be a herculean task. “The days leading up to March 18th were crazy — we needed to make sure things like lab safety and ordering, and receiving supplies were functional remotely, but also that we had enough people on-site to keep things running,” said Greg Ryan, associate director of procurement services.Ryan along with dozens of other Wyss members from the operations, administration, and facilities teams jumped in and contributed their time and expertise to ensure that COVID-19 research could continue smoothly. Some of their on-the-fly solutions include a makeshift shipping and receiving room that is currently set up in the dining area of one of the Institute’s floors, and a wireless headset-enabled “buddy system” that the researchers use to check in with each other while they’re working in the lab.“Normally we have about 250 people working in the lab spaces at our Longwood site on a given day, so right now with only about 45 people cleared to be here doing COVID-19 research, you actually have to hunt for people if you need them,” said Rob Rasmussen, the Wyss Institute’s director of research operations. “All you hear is the white noise of the ventilation system, no conversations — it’s very calm and quiet, almost like being in an ashram.”Coronavirus collaborationsBut just because the labs seem calm doesn’t mean work isn’t getting done — if anything, more is happening now than ever. “The collaborations I’m seeing are unprecedented,” said Rasmussen. “George Church, Jim Collins, David Mooney, and Don Ingber are all applying their unique approaches to develop a surrogate non-COVID-19 coronavirus for their labs to study, which I’ve never seen before. COVID-19 is really serving as this binding force to bring major players together to solve a problem that the world urgently needs to have solved.”While the majority of the Wyss Institute’s employees, students, and postdocs are working from home, those in the lab are taking on the coronavirus pandemic on a number of fronts, including redesigning much-needed face masks for mass manufacturing, creating rapid diagnostic tests, identifying existing drugs that might treat the virus or prevent its spread, and engineering a vaccine to prevent healthy people from getting sick.,“This period of time when so many other activities have slowed down has allowed people to focus their energies on the specific problem of COVID-19 rather than having a portfolio of multiple different activities, which is a big shift in our mode of operation. I think that this kind of flexibility and scrappiness has been built into the Wyss Institute, because from the very beginning we committed ourselves to doing things differently than a typical university lab. Reorienting our research in response to an urgent, pressing need on a dime came very naturally to us,” said Antoniou. Design School turns 3D printers into PPE producers
IDC recently reported on the power swaps occurring in the sales industry: “A rich dialog has shifted online and away from the sales person.” Accenture noted the trend similarly, saying “the customer journey is now dynamic, accessible and continuous.”Customers no longer need to be handheld through the typical discover and consider phases of the buying cycle. In fact, 60% of the buying cycle is complete before the vendor is engaged. Where customers want and need vendor input is during the evaluation, purchase and use phases.Across these phases, they expect vendors to be able to engage with them instantly via multiple online and social channels in a highly interactive manner. They also want vendors to learn from what is said on social platforms and adjust their strategies accordingly.Inside Sales provides an agile platform that attracts the empowered buyer. According to the Department of Labor Statistics, Inside Sales is estimated to reach 3.4 million employees by 2020. Today, Inside Sales represents 21% of overall sales headcount and growth significantly outpaced Field Sales in 2013 (3.9% vs. 1.3%, respectively).Businesses are taking notice and enhancing their own Inside Sales operations. For instance, Inside Sales runs SAP’s <1000-employee business. At IBM, 15% of cloud wins are from Inside Sales’ social media efforts. And in Q3 2014, Oracle hired and socially trained 400 cloud Inside Sales representatives.Inside Sales also offers a lower cost model. Cost to business becomes more critical than ever when competing against startups and “as a service” providers. In those markets, Inside Sales is quite often the only go-to-market strategy.Inside Sales also enables companies to bring on fresh talent and train them on the ins and outs of the products, services and organization itself. It’s a great opportunity to groom the next generation of sales superstars.EMC: Out Front on Inside SalesFortunately, EMC has built a strong foundation to embrace this era of the empowered buyer and develop a strong bond on whatever platform they choose to engage with us.Inside Sales is essential in several aspects:We protect ourselves from the lower end of the market that otherwise would be at risk to up and coming competitors. We feed the talent pool for Field Sales, especially around diversity. Recently, we promoted 62 Inside Sales representatives to Field Sales roles and have five Inside Sales alumni in Field Sales leadership roles.We provide a strategic lever for demand generation. In 2014, Inside Sales produced $2.6B in forecasted pipeline opportunities. We have created an agile environment that pushes the envelope on virtual sales skills, using video and social selling techniques. This makes us highly attractive to the empowered buyer.I am a 25-year veteran of high tech and I have never been so excited for the opportunities that lie ahead for Inside Sales and EMC as whole. We have the leading edge right now in this industry and our challenge is to keep it that way!
The game has changed. As CIOs and IT professionals, we were comfortable with controlling the environment; talking in ERP terms and timelines; and in using a liquidation/unit cost financial model to manage our operations. However, the landscape has changed and our business users expect and need IT’s help in driving agility, intelligence, innovation and value. To remain relevant, CIOs and IT organizations must reenergize IT.On October 6th, EMC celebrated the tremendous strides the company is making to dramatically enhance our Total Customer Experience (TCE) globally. Like other EMC customers, my team and I wholeheartedly embraced cloud and big data analytics, as well as mobile and social technologies to innovate and propel us forward. That said, building on my blog earlier this year, I believe that digitization is the key to improving TCE and transforming how businesses run for the future.Technology plays a significant role in digitizing processes, but it is just one piece of the puzzle. We must first change our overall approach. Unlike traditional tight controls and restrictive IT systems, a digitally transformed IT environment makes it easier for business to engage with customers. By leveraging digitization and automation, we differentiate our business; deliver operational efficiencies and world-class customer experiences; and empower employees with the flexibility to cut through bureaucracy.At EMC, we optimize our own IT processes and simplify, automate and digitize our service catalog and a variety of services for our users. For example, to help EMC’s engineering and DevOps communities focus less on the underlying technology and more on their task at hand, we automated the provisioning and delivery of two new services – Infrastructure as a Service and Platform as a Service. By introducing Infrastructure as a Service, we decreased unit costs by 24% and now deliver infrastructure much faster. These services are just scratching the surface of what we can do to make our users more efficient and productive.Additionally, to move to this more contemporary, elastic and on demand IT model, EMC’s IT organization realigned our organization to have a stronger partnership and seat at the table with the company’s lines of business. As a trusted advisor, our leaders must not only leverage robust automated processes to deliver programs on time and on budget, but have a deep understanding of the business unit’s needs to help, or in some cases, lead its digital transformation.The bottom line – the traditional IT pace and approach is obstructing success and will make old ways of operating IT irrelevant. To move at the speed of business, CIOs and IT professionals must anticipate business needs; simplify and lean out redundant process; embrace the latest technologies; and automate and digitize as much as possible. Not only will this transform how IT organizations are run and improve the total customer experience internally, but it will have a long lasting positive impact for our companies.
Maximizing power visibility and control with OpenManage Enterprise Power ManagerAs data center professionals, we are often faced with operational efficiency objectives from the business. These objectives become more demanding as the IT infrastructure transforms. At times, the need to maintain and control a reliable, cost-efficient environment can become overwhelming. Fortunately, Dell EMC puts the power in your hands. With the release of the new Dell EMC OpenManage Enterprise Power Manager, you can quickly identify areas to gain efficiencies and reduce costs.OpenManage Enterprise Power Manager gives you the tools to recognize the power and thermal health of your servers. The intuitive user interface helps you monitor, set alerts, and cap the power within your server infrastructure. Additionally, you can monitor and set alerts for temperature fluctuations. The comprehensive dashboard helps you view, manage, measure, and control server power consumption so you can easily increase infrastructure performance.The enhanced power management visibility and control provided by OpenManage Enterprise Power Manager is a critical tool in your quest to sustain uninterrupted power in your data center. Power interruptions and downtime are very costly, even detrimental, to your data center. With OpenManage Enterprise Power Manager, you can reduce power related downtime, and deliver a more cost-efficient IT environment.Centralized control of power, thermal and server lifecycle management Dell EMC OpenManage Enterprise Power Manager is delivered as a plugin to the Dell EMC OpenManage Enterprise console. The plugin extends the OpenManage FlexSelect value proposition with a unified dashboard that lets you manage data center power and server lifecycle tasks from the same interface. The Power Manager plugin is included with the OpenManage Enterprise Advanced License. After OpenManage Enterprise is installed, the Power Manager plugin can be easily activated by hitting “Install” on the Consoles and Extensions page of OpenManage Enterprise.Once the Power Manager plugin is installed, you can view power and thermal status directly from the OpenManage Enterprise interface. You can also view power and thermal alerts on the main OpenManage Enterprise dashboard. Finally, when you enable the plugin, you enable power and thermal reports in the OpenManage Enterprise reports list.Power and thermal visibility are the first step. OpenManage Enterprise Power Manager also gives you the information you need to make power-saving decisions and the tools you need to control the power in your infrastructure.Reporting: As infrastructures transform, understanding the power history is important for planning and expansion. Reporting in Power Manager can highlight optimal placement of new servers, energy usage for specific groups, and identification of inefficient servers. Users can download various reports to view key information for optimal decision making.Emergency Power Reduction (EPR): Many data centers require a comprehensive business continuity plan for unpredictable events. In the event of an urgent situation, Power Manager EPR can reduce power consumption and heat generation. In a few seconds, users can easily invoke EPR and continue server operation with minimal power. Once the disruptive event is resolved, Power Manager allows users to return to previous power levels.Combined with OpenManage Enterprise, OpenManage Enterprise Power Manager uses an intuitive interface to automate, alert, and create reports that help you maximize resources, lower energy consumption, and prevent outages. Using the data reported with Power Manager, you can identify individual servers and groups of servers, which would benefit from relocation, workload adjustment, and power reduction. With Power Manager in the data center, you have the power to lower power costs, and reduce downtime.Visit dellemc.com for more information on OpenManage Enterprise Power Manager.To learn more about PowerEdge servers, visit dellemc.com/servers, or join the conversation on Twitter @DellEMCservers.
TOKYO (AP) — One of the biggest unanswered questions about the Tokyo Olympics deals with fans. Will there be any from abroad? And will fans of any sort be allowed in outdoor stadiums or smaller indoor arenas? Organizing committee President Yoshiro Mori says “no spectators is one of the options.” The International Olympic Committee and Tokyo organizers will roll out their “Playbook” next week. The detailed plan about how to hold the games during a pandemic will set down strict rules for thousands of athletes arriving in Japan. The Nikkan Sports newspaper reports that organizers are expected to announce “soon” that fans from abroad will not be allowed to attend.
ROME (AP) — Former European Central Bank chief Mario Draghi has agreed to try to form a non-political government to steer Italy through the coronavirus pandemic. Italian President Sergio Mattarella on Wednesday gave Draghi a mandate to put together a new government to replace caretaker Premier Giuseppe Conte’s collapsed coalition of the 5-Star Movement and Democratic Party. The task won’t be easy, since the populist party with the most seats in Parliament said it won’t support a Draghi government. Nevertheless markets welcomed indications that Italy’s latest political crisis might get resolved at least for the next few months. Draghi is credited with having saved the euro during the peak of Europe’s debt crisis in 2012.
In the summer of 1980, Shirley Grauel turned down a job working in a basement.A mother with young children, she called the University regarding an ad for an administrative secretary position. When the University called back about a new, nine-month job working with the student-run campus newspaper, she knew it was perfect.“And here I am now, 30 years later, working in a basement of a building,” she said on her second-to-last day as The Observer office manager.Known for her hugs, her candy bowl and her daily line-up of daytime television, Shirley has been a constant presence at The Observer, and staffers over the years have come to know her as their second mother.“I love interacting with everybody every day. They stay the same age, but I keep getting older, but I never felt the gap,” she said. “I respected the students, and it just worked out so well.”Shirley’s time at The Observer has not only shaped her life, but her family’s. Her daughter, Jill O’Hara, said her earliest memories of her mom are of her working at The Observer.When she was very young, Shirley would bring her to work in the LaFortune offices when she was too sick for school and she would watch “The Price is Right” with the students working.“It took me a long time to understand what my mom meant when I’d hear her tell people that she could ‘sell her job because it’s so great,” Jill said.As a student at Notre Dame in the 1990s, Jill said she was touched by how much her mother was loved on campus.“When students who I didn’t even know would approach me and tell me how wonderful she is … I would smile and agree with them, and then wonder if it was odd that my mom was more popular on campus than I was,” she said.Jill said Shirley’s love for her job and for the students who work at The Observer “is genuine and deep.”“I don’t think she realizes the hearts she’s touched over the years … but I do. She is 100 percent the person she appears to be: loving, committed, loyal, nurturing,” she said. “I am incredibly proud that this mom to so many actually is my mom.”Though to many, 30 years in one position might seem like an eternity, it didn’t feel that way to Shirley.“Every day was special,” she said. “Where else would you get hugs everyday, and students walking up to say ‘I love you?’ I could have a bad day, but I don’t ever leave here in a bad mood.”During her time at The Observer, Shirley has collected many memories and stories to share about the students she worked with — her second family. She recalled one staffer even calling her from the recovery room after delivering her first baby.“The weddings I’ve been invited to, the e-mails I get that they’re having tailgates or the notes that are left on my desk every Saturday during the football season … I feel like I can go anywhere and I can find one of the former people,” she said.After about 10 years on the job, Shirley realized she had a lucky feeling.“I realized not once had I gotten up in the morning and said, ‘Oh man, I’ve got to go to work.’ It was always, ‘I get to go to work,’” she said. “I wish everyone could experience that.”Observer alumni will reunite the weekend of the Blue-Gold game for a retirement party for Shirley, an event she is very excited about.“I can’t wait to see everyone,” she said.Preparing to return to campus for the reunion party, Observer alumni shared memories of Shirley.Bruce Oakley, Class of 1980, returned to campus looking for a job after graduation and started working with Shirley at The Observer after serving as a copy editor his senior year.He’ll be coming back again for the party, and told stories of those early years: installing typesetting machines, listening to Blondie, babysitting for Shirley’s children.“Shirley proudly shared her life with us,” he said. “She has strength enough for a family that’s been growing for 30 years.“My message to Shirley: ‘Mom, the kids are all right. And we’re coming home.’”Though it hasn’t always been smooth sailing in The Observer office, the staff was always able to rely on Shirley, said John Lucas, a member of the Class of 1996 who served as Editor-in-Chief from 1995-96.“Shirley always was a tremendous, steadying force: calm, fun and kind. She was in the eye of the hurricane, with the chaos that is The Observer swirling all around her,” he said.The current staff, including Editor-in-Chief Matt Gamber, isn’t quite ready to Shirley go.“I’ve been incredibly blessed to have known Shirley for the past three years, and I can’t thank her enough for the countless smiles and hugs that have brightened long nights and early mornings in the office,” Gamber said. “It will be a challenge to move forward without her, both from a personal and a professional standpoint, but on behalf of the entire staff, Shirley, I wish you nothing but the best as you enjoy your retirement. We will miss you.”Now that her time at The Observer has come to a close, Shirley said she is “going to become a traveler and a full-time grandma.”Shirley has plans for an Alaskan cruise this June with her husband Craig, also retired, and the Grauels are renting a condo in Florida for four weeks next spring.“If Craig wasn’t at home, I probably wouldn’t be retired … but things happen for a reason, and it’s time,” she said. “Thirty years … that’s enough.”
In honor of the original AnTostal, a College celebration of springtime in the 1960s, the Saint Mary’s Student Activities Board (SAB) will host SMC Tostal, an event featuring a free concert and a variety of other activities.“We have it to give the students the chance to relax a bit before finals,” SAB president Michele Peterson, a senior, said. Peterson said the Tostal activities begin at noon on Thursday. Activities include inflatables on the Library Green from noon to 4 p.m, including a bungee run, obstacle course, slide and human spheres, as well as a rock wall and mechanical bull.“These are all free, so students can stop by between classes and have a bit of fun,” Peterson said. “There will also be a food vendor with ‘fudge puppies,’ which are basically waffles on a stick covered with chocolate and toppings, and freshly squeezed orange, lemon and lime juice.”In the Spes Unica Hall Atrium and Student Center Atrium, henna tattoo artists will offer free tattoos. A photo booth will also be available to students in the dining hall during dinner.The day will end with a concert featuring Josh Kelley and opening act Jon McLaughlin.Tickets are free and available to Notre Dame, Saint Mary’s and Holy Cross students in the Student Center Atrium today from 11 a.m. to 2 p.m. and 4 p.m. to 7 p.m.“I love that SAB can provide the students with a day of fun,” Peterson said. “We all work so hard, and by the end of the spring semester, we are often stressed with oncoming exams. SMC Tostal gives students the chance to relax for a change.”Peterson said the Tostal is a chance to allow students to relax for free.“We are lucky that we can provide such a fun-filled day, all for free, just for the students.,” Peterson said. “They really deserve this, and SAB really hopes they enjoy all the events we planned.”
Students, faculty and staff may pay their respects to Saint Mary’s sophomore Ziqi Zhang, who passed away Oct. 18, on Wednesday during a public visitation with her family, according to an email to all College students Monday afternoon. Zhang, 19, died from injuries sustained in a car-bicycle accident outside the entrance to Saint Mary’s at State Route 933. A resident of Regina Hall, Zhang was a dual-degree student majoring in mathematics at Saint Mary’s and taking engineering classes at Notre Dame. She was a resident of Jiangsu Province in China. Her parents, Ruicheng and Yongli Zhang, traveled to Saint Mary’s from Xuzhou, China, last week. They arranged for a public visitation Wednesday at Kaniewski Funeral Home from noon to 2 p.m. The funeral home is located at 3545 North Bendix Drive in South Bend. Shuttle bus service will be available to students and will depart from the front of Le Mans Hall at Saint Mary’s, the email stated. The bus is scheduled to leave every half hour between 11:45 a.m. and 1:15 p.m., and it will return to campus every half hour between 12 and 2 p.m. A memorial fund has been established for Zhang’s family, and contributions can be made by sending donations to Karen Johnson, vice president for Student Affairs, Saint Mary’s College, 175 Le Mans Hall, Notre Dame, IN 46556. Checks should be made payable to Saint Mary’s College and indicate in the memo line the donation should be directed to the Ziqi Zhang family. College President Carol Ann Mooney expressed her sympathy last week during a memorial service for Zhang Oct. 23 at Regina Chapel. “Each of us has lost a sister,” Mooney said. “It is terribly difficult to lose a young person with so much talent and so much promise. Ziqi’s death leaves a hole in the Saint Mary’s community. Mooney told the crowd gathered at the memorial service that the College would welcome the Zhang family to the best of its ability. “For her family, this is an unspeakable grief,” she said. “When they arrive on campus, we will make every effort to let them know how valued Ziqi was, what a positive contribution to Saint Mary’s she was and that she had a home here.”